Article

Niclosamide Suppresses the Expansion of Follicular Helper T Cells and Alleviates Disease Severity in Two Murine Models of Lupus via STAT3

2020-11-19

Abstract excerpt

<title>Abstract</title> <bold>Background. </bold>Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producing plasma cells (PCs). The IL-6 and IL-21 cytokine-mediated STAT3 signaling are crucial for the differentiation to TFH cells. Niclo...

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Literature Corpus work: 2402175f-8767-5acb-bb30-439f52ae2adf
DOI: 10.21203/rs.3.rs-110581/v1

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