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Article

Pneumococcal Surface Protein A Plays a Major Role in Streptococcus pneumoniae-Induced Immunosuppression.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2016

Saumyaa, Pujanauski Lindsey, Colino Jesus, Flora Michael, Torres Raul M, Tuomanen Elaine, Snapper Clifford M

Abstract excerpt

Intact, inactivated Streptococcus pneumoniae [including the unencapsulated S. pneumoniae, serotype 2 strain (R36A)] markedly inhibits the humoral immune response to coimmunized heterologous proteins, a property not observed with several other intact Gram-positive or Gram-negative bacteria. In this study, we determined the nature of this immunosuppressive property. Because phosphorylcholine (PC), a major haptenic...

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Identifiers

PMID: 27029587
DOI: 10.4049/jimmunol.1502709
PMCID: PMC4868640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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