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Article

Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2002

Mold Carolyn, Rodic-Polic Bojana, Du Clos Terry W

Abstract excerpt

Streptococcus pneumoniae is an important human pathogen and the most common cause of community-acquired pneumonia. Both adaptive and innate immune mechanisms provide protection from infection. Innate immunity to S. pneumoniae in mice is mediated by naturally occurring anti-phosphocholine (PC) Abs and complement. The human acute-phase reactant C-reactive protein (CRP) also protects mice from lethal S. pneumoniae...

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Share to Antibodies, Bacterial
Share to Complement System Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Injections, Intravenous

Share to Phosphorylcholine

Share to Pneumococcal Infections

Share to Polysaccharides, Bacterial

Share to Receptors, IgG

Source

Identifiers

PMID: 12055255
DOI: 10.4049/jimmunol.168.12.6375

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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