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Article

XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner.

Biology of sex differences - 14 Mar 2024

Amato-Menker Carly J, Hopen Quinn, Pettit Andrea, Gandhi Jasleen, Hu Gangqing, Schafer Rosana, Franko Jennifer

Abstract excerpt

BACKGROUND: Differences in male vs. female immune responses are well-documented and have significant clinical implications. While the immunomodulatory effects of sex hormones are well established, the contributions of sex chromosome complement (XX vs. XY) and gut microbiome diversity on immune sexual dimorphisms have only recently become appreciated. Here we investigate the individual and collaborative influences...

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Identifiers

PMID: 38486287
DOI: 10.1186/s13293-024-00597-0
PMCID: PMC10938708

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