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Article

IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice.

Molecular immunology - 1 Mar 2022

Hu Yi, Li Lian, Xu Wenchun, Wu Kaifeng, Xiao Jiangming, Peng Yang, Liu Yusi, Yin Yibing, Zhang Xuemei

Abstract excerpt

The fusion protein DnaJ-ΔA146Ply is protective against pneumococcal infections in mice. However, we found that immunized IL-4-/- mice showed significant lower survival rates and higher bacterial loads than did wild-type (WT) mice after being challenged. We explored the role of IL-4 in the protective immunity conferred by DnaJ-ΔA146Ply. Our results showed that there were no significant differences in antibody...

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PMID: 35114487
DOI: 10.1016/j.molimm.2022.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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