Article
A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection.
Disease models & mechanisms - 26 Mar 2020
Twentyman Joy, Morffy Smith Catherine, Nims Julia S, Dahler Aubree A, Rosen David A
Abstract excerpt
Klebsiella pneumoniae represents a growing clinical threat, given its rapid development of antibiotic resistance, necessitating new therapeutic strategies. Existing live-infection models feature high mortality rates, limiting their utility in the study of natural adaptive immune response to this pathogen. We developed a preclinical model of pneumonia with low overall mortality, in which previously exposed mice...
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