Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B and CD4+ T-cell expression of TLR2 is critical for optimal induction of a T-cell-dependent humoral immune response to intact Streptococcus pneumoniae.

European journal of immunology - 1 Dec 2008

Vasilevsky Sam, Chattopadhyay Gouri, Colino Jesus, Yeh Tze-Jou, Chen Quanyi, Sen Goutam, Snapper Clifford M

Abstract excerpt

TLR2(-/-) mice immunized with Streptococcus pneumoniae (Pn) elicit normal IgM, but defective CD4(+) T-cell-dependent type 1 IgG isotype production, associated with a largely intact innate immune response. We studied the T-cell-dependent phosphorylcholine (PC)-specific IgG3 versus the T-cell-independent IgM response to Pn to determine whether TLR2 signals directly via the adaptive immune system. Pn-activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin G

Share to Immunoglobulin M

Share to Interferon-gamma

Share to Mitosis

Share to Streptococcus pneumoniae

Share to Toll-Like Receptor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 19003933
DOI: 10.1002/eji.200838484
PMCID: PMC2759084

Genes

TLR2
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B and CD4+ T-cell expression of TLR2 is critical for optimal induction of a T-cell-dependent humoral immune response to intact Streptococcus pneumoniae.PMID 19003933Read ↗

Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2Semantic proximity Read ↗

Role of Toll-like receptor 2 in innate resistance to Group B Streptococcus.Semantic proximity Read ↗

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.Semantic proximity Read ↗

Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins.Semantic proximity Read ↗

Pneumococcal peptidoglycan-polysaccharides regulate Toll-like receptor 2 in the mouse middle ear epithelial cells.Semantic proximity Read ↗

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine LupusSemantic proximity Read ↗

Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.Semantic proximity Read ↗

Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors.Semantic proximity Read ↗

IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice.Semantic proximity Read ↗

Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathwaySemantic proximity Read ↗

NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.Semantic proximity Read ↗

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.