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Article

Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection.

PloS one - 1 Jan 2014

Zhang Yongmei, Mao Richeng, Yan Ran, Cai Dawei, Zhang Yijun, Zhu Haoxiang, Kang Yaoyue, Liu Hongyan, Wang Jinyu, Qin Yanli, Huang Yuxian, Guo Haitao, Zhang Jiming

Abstract excerpt

The persistence of hepatitis B virus (HBV) infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA), which serves as transcription template for viral mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG islands, and that the minichromosome structure of cccDNA is epigenetically regulated by DNA methylation. However, the regulatory effect of each CpG island...

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Share to CpG Islands
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

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Source

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Identifiers

PMID: 25337821
DOI: 10.1371/journal.pone.0110442
PMCID: PMC4206413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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