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Replicative Activity of Hepatitis B Virus Is Negatively Associated with Methylation of Covalently Closed Circular DNA in Advanced Hepatitis B Virus Infection

1 Jan 2011

Abstract excerpt

OBJECTIVES: The aim of this study was to examine the methylation status of intrahepatic hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and to elucidate the possible relationship between the cccDNA methylation and viral replicative activity in patients with HBV-related liver cirrhosis (HBV-LC). METHODS: The methylation status of HBV cccDNA was investigated by bisulfite sequencing in nonneoplastic...

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PMID: 21242658
DOI: 10.1159/000321450

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