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Article

HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state

1 Jun 2011

Abstract excerpt

HBV covalently closed circular DNA (cccDNA) is the template for the transcription of HBV. HBV core protein (HBc) is a main component of the HBV cccDNA minichromosome. However, the function of HBc in cccDNA is not fully understood. In light of recent findings that HBV cccDNA may be regulated epigenetically, we analyzed the binding of HBc to cccDNA and the impact of HBc on cccDNA epigenetic profile in the liver...

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PMID: 21546797
DOI: 10.4161/epi.6.6.15815

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