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Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs

1 Jan 2013

Abstract excerpt

The hepatitis B virus (HBV) genome forms a covalently closed circular DNA (cccDNA) minichromosome that persists in the nucleus of virus-infected hepatocytes. HBV cccDNA serves as the template for viral mRNA synthesis and is subject to epigenetic regulation by several mechanisms, including DNA methylation and histone acetylation. Recently, microRNAs (miRNAs), a class of small non-coding RNAs, were also directly...

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PMID: 24133502
DOI: 10.3389/fgene.2013.00202

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