Article
Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues.
Scientific reports - 22 May 2015
Jain Surbhi, Chang Ting-Tsung, Chen Sitong, Boldbaatar Batbold, Clemens Adam, Lin Selena Y, Yan Ran, Hu Chi-Tan, Guo Haitao, Block Timothy M, Song Wei, Su Ying-Hsiu
Abstract excerpt
Hepatitis B virus (HBV) is a hepatotropic virus causing hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The methylation status of the HBV DNA in its different forms can potentially provide insight into the pathogenesis of HBV-related liver diseases, including HCC, however this is unclear. The goal of this study is to obtain comprehensive DNA methylation profiles of the three putative CpG islands in the...
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