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Article

The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2014

Khatlani T, Pradhan S, Da Q, Gushiken F C, Bergeron A L, Langlois K W, Molkentin J D, Rumbaut R E, Vijayan K V

Abstract excerpt

BACKGROUND: Calcium-dependent signaling mechanisms play a critical role in platelet activation. Unlike calcium-activated protease and kinase, the contribution of calcium-activated protein serine/threonine phosphatase in platelet activation is poorly understood. OBJECTIVE: To assess the role of catalytic subunit of protein phosphatase 2B (PP2B) or calcineurin in platelet function. RESULTS: Here, we showed that an...

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Identifiers

PMID: 25330904
DOI: 10.1111/jth.12761
PMCID: PMC4268338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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