Article
A new role for the A2b adenosine receptor in regulating platelet function.
Journal of thrombosis and haemostasis : JTH - 1 Apr 2010
Yang D, Chen H, Koupenova M, Carroll S H, Eliades A, Freedman J E, Toselli P, Ravid K
Abstract excerpt
BACKGROUND: Activation of platelets is a critical component of atherothrombosis and plays a central role in the progression of unstable cardiovascular syndromes. Adenosine, acting through adenosine receptors, increases intracellular cAMP levels and inhibits platelet aggregation. The A2a adenosine receptor has already been recognized as a mediator of adenosine-dependent effects on platelet aggregation, and here we...
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