Article
Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.
Science signaling - 24 May 2016
Donner Lili, Fälker Knut, Gremer Lothar, Klinker Stefan, Pagani Giulia, Ljungberg Liza U, Lothmann Kimberley, Rizzi Federica, Schaller Martin, Gohlke Holger, Willbold Dieter, Grenegard Magnus, Elvers Margitta
Abstract excerpt
Cerebral amyloid angiopathy (CAA) is a vascular dysfunction disorder characterized by deposits of amyloid-β (Aβ) in the walls of cerebral vessels. CAA and Aβ deposition in the brain parenchyma contribute to dementia and Alzheimer's disease (AD). We investigated the contribution of platelets, which accumulate at vascular Aβ deposits, to CAA. We found that synthetic monomeric Aβ40 bound through its RHDS...
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