Article
Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis.
PloS one - 1 Jan 2011
Qumsieh Rula Y, Ali Bassam R, Abdulrazzaq Yousef M, Osman Ossama, Akawi Nadia A, Bastaki Salim M A
Abstract excerpt
CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants. It displays inter-individual and inter-ethnic variability in activity ranging from complete absence to excessive activity which causes adverse drug reactions and toxicity or therapy failure even at normal drug doses. This variability is due to...
Topics
- Cytochrome P-450 CYP2D6
- Gene Frequency
- Genotype
- Humans
- Reverse Transcriptase Polymerase Chain Reaction
- United Arab Emirates