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Article

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.

Neurobiology of disease - 1 Jan 2015

Aboud Asad A, Tidball Andrew M, Kumar Kevin K, Neely M Diana, Han Bingying, Ess Kevin C, Hong Charles C, Erikson Keith M, Hedera Peter, Bowman Aaron B

Abstract excerpt

Poorly-defined interactions between environmental and genetic risk factors underlie Parkinson's disease (PD) etiology. Here we tested the hypothesis that human stem cell derived forebrain neuroprogenitors from patients with known familial risk for early onset PD will exhibit enhanced sensitivity to PD environmental risk factors compared to healthy control subjects without a family history of PD. Two male siblings...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25315681
DOI: 10.1016/j.nbd.2014.10.002
PMCID: PMC4394022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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