Article
Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines.
Stem cell reports - 12 May 2015
Shaltouki Atossa, Sivapatham Renuka, Pei Ying, Gerencser Akos A, Momčilović Olga, Rao Mahendra S, Zeng Xianmin
Abstract excerpt
In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH(+) neurons was decreased in Parkinson's disease (PD) patient-derived neurons carrying various mutations in PARK2 compared with an age-matched control subject. This reduction was accompanied by alterations in mitochondrial:cell volume...
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