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Article

Parallel neurodegenerative phenotypes in sporadic Parkinson's disease fibroblasts and midbrain dopamine neurons.

Progress in neurobiology - 1 Oct 2023

Corenblum M J, McRobbie-Johnson A, Carruth E, Bernard K, Luo M, Mandarino L J, Peterson S, Sans-Fuentes M A, Billheimer D, Maley T, Eggers E D, Madhavan L

Abstract excerpt

Understanding the mechanisms causing Parkinson's disease (PD) is vital to the development of much needed early diagnostics and therapeutics for this debilitating condition. Here, we report cellular and molecular alterations in skin fibroblasts of late-onset sporadic PD subjects, that were recapitulated in matched induced pluripotent stem cell (iPSC)-derived midbrain dopamine (DA) neurons, reprogrammed from the...

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Identifiers

PMID: 37451330
DOI: 10.1016/j.pneurobio.2023.102501
PMCID: PMC11249208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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