Article

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment

2019-10-22

Abstract excerpt

The etiology of Parkinson’s disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the PTEN-induced putative kinase 1 ( PINK1 ) gene involved in mitochondrial homeostasis, vesicle trafficking, and autophagy, are sufficient to cause PD. By comparing PD patient-derived cells, we show dif...

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Literature Corpus work: 66d728e3-04e2-5171-8033-725be141853e
DOI: 10.1101/813089

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