A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival

Abstract excerpt

Abstract Common disorders, including diabetes and Parkinson’s disease, are caused by a combination of environmental factors and genetic susceptibility. However, defining the mechanisms underlying gene-environment interactions has been challenging due to the lack of a suitable experimental platform. Using pancreatic β-like cells derived from human pluripotent stem cells (hPSCs), we discovered that a commonly used...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CRISPR and Genetic Engineering
• Share to Pancreatic function and diabetes
• Share to Pluripotent Stem Cells Research