Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.

doi:10.1016/j.cell.2013.11.009

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Article

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.

Cell - 5 Dec 2013

Ryan Scott D, Dolatabadi Nima, Chan Shing Fai, Zhang Xiaofei, Akhtar Mohd Waseem, Parker James, Soldner Frank, Sunico Carmen R, Nagar Saumya, Talantova Maria, Lee Brian, Lopez Kevin, Nutter Anthony, Shan Bing, Molokanova Elena, Zhang Yaoyang, Han Xuemei, Nakamura Tomohiro, Masliah Eliezer, Yates John R, Nakanishi Nobuki, Andreyev Aleksander Y, Okamoto Shu-ichi, Jaenisch Rudolf, Ambasudhan Rajesh, Lipton Stuart A

Abstract excerpt

Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, patient-derived stem cell model of PD allowing comparison of A53T α-synuclein (α-syn) mutant cells and isogenic...

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PMID: 24290359
DOI: 10.1016/j.cell.2013.11.009
PMCID: PMC4028128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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