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Article

Copy number loss or silencing of apoptosis-effector genes in cancer.

Gene - 1 Jan 2015

Mauro James A, Butler Shanitra N, Ramsamooj Michael, Blanck George

Abstract excerpt

Cancer cells undergo a variety of DNA copy number gains and losses (CNV), raising two important questions related to cancer development: (i) Which genes are affected? (ii) And how do CNVs, that do not represent complete deletions but do represent gene-dosage alterations, impact cancer cell functions? Recent studies have indicated that CNVs in cancer can impact genes for regulatory proteins long known to be...

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Identifiers

PMID: 25307873
DOI: 10.1016/j.gene.2014.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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