Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenes without a Neighboring Tumor-Suppressor Gene Are More Prone to Amplification.

Molecular biology and evolution - 1 Apr 2017

Wu William K K, Li Xiangchun, Wang Xiansong, Dai Rudin Z W, Cheng Alfred S L, Wang Maggie H T, Kwong Thomas, Chow Tai C, Yu Jun, Chan Matthew T V, Wong Sunny H

Abstract excerpt

Focal copy number gains or losses are important genomic hallmarks of cancer. The genomic distribution of oncogenes and tumor-suppressor genes (TSG) in relation to focal copy number aberrations is unclear. Our analysis revealed that the mean distance of TSGs from oncogenes was significantly shorter than that of noncancer genes, suggesting that oncogenes and TSGs tend to be in close physical proximity in the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Nucleic Acid
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Genomics

Share to Neoplasms

Share to Oncogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 28087780
DOI: 10.1093/molbev/msw295
PMCID: PMC5400371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenes without a Neighboring Tumor-Suppressor Gene Are More Prone to Amplification.PMID 28087780Read ↗

Pan-cancer patterns of somatic copy number alteration.Semantic proximity Read ↗

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations.Semantic proximity Read ↗

Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study.Semantic proximity Read ↗

Two Distinct Categories of Focal Deletions in Cancer GenomesSemantic proximity Read ↗

Candidate targets of copy number deletion events across 17 cancer typesSemantic proximity Read ↗

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancersSemantic proximity Read ↗

The Evolution of Human Cancer Gene Duplications across MammalsSemantic proximity Read ↗

FocalScan: Scanning for altered genes in cancer based on coordinated DNA and RNA change.Semantic proximity Read ↗

Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions.Semantic proximity Read ↗

Understanding genomic alterations in cancer genomes using an integrative network approach.Semantic proximity Read ↗

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancersSemantic proximity Read ↗

Characterizing the cancer genome in lung adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.