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Article

Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study.

BMC genomics - 22 Aug 2016

Zhao Min, Zhao Zhongming

Abstract excerpt

BACKGROUND: Tumor suppressor genes (TSGs) encode the guardian molecules to control cell growth. The genomic alteration of TSGs may cause tumorigenesis and promote cancer progression. So far, investigators have mainly studied the functional effects of somatic single nucleotide variants in TSGs. Copy number variation (CNV) is another important form of genetic variation, and is often involved in cancer biology and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27556634
DOI: 10.1186/s12864-016-2904-y
PMCID: PMC5001246

Genes

MTAP
FBXO25
MCPH1
PTEN
SMAD4
TRIM35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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