Article

Increased expression of a subset of genes within reduced copy number regions across multiple cancer types

2026-04-14

Abstract excerpt

<h4>ABSTRACT</h4> The TGIF1 transcription factor gene is present on chromosome 18, which is subject to whole chromosome copy number reduction in colon cancer. Despite this, TGIF1 expression is significantly higher in cancer than in normal. In mice complete deletion of Tgif1 reduced tumor burden in an Apc mutant model of intestinal cancer. Here we show that reducing TGIF1 expression in a human colon cancer ce...

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Literature Corpus work: ce82ecb4-8054-55d9-8fce-36f91a4f3167
DOI: 10.64898/2026.04.10.717791

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