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Article

Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.

Virology - 1 Nov 2014

Barrett Bradley S, Guo Kejun, Harper Michael S, Li Sam X, Heilman Karl J, Davidson Nicholas O, Santiago Mario L

Abstract excerpt

APOBEC1 is a cytidine deaminase involved in cholesterol metabolism that has been linked to retrovirus restriction, analogous to the evolutionarily-related APOBEC3 proteins. In particular, murine APOBEC1 was shown to inhibit Friend retrovirus (FV) in vitro, generating high levels of C-to-T and G-to-A mutations. These observations raised the possibility that FV infection might be altered in APOBEC1-null mice. To...

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Source

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Identifiers

PMID: 25303118
DOI: 10.1016/j.virol.2014.09.006
PMCID: PMC4430097

Genes

APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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