Article
Obesity has an interactive effect with genetic variation in the activating transcription factor 6 gene on the risk of pre-diabetes in individuals of Chinese Han descent.
PloS one - 1 Jan 2014
Gu Nan, Ma Xiaowei, Zhang Junqing, Dong Aimei, Jin Mengmeng, Feng Nan, Zhang Hong, Guo Xiaohui
Abstract excerpt
Endoplasmic reticulum (ER) stress is one of the contributing factors to the development of β-cell failure in type 2 diabetes. ER stress response through ATF6 has been shown to play an important role in insulin resistance and pancreatic β-cell function. We investigated whether genetic polymorphisms in ATF6 were associated with the risk of pre-diabetes in a Chinese Han population, and whether they had a synergistic...
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