Article
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2009
Meex Steven J R, Weissglas-Volkov Daphna, van der Kallen Carla J H, Thuerauf Donna J, van Greevenbroek Marleen M J, Schalkwijk Casper G, Stehouwer Coen D A, Feskens Edith J M, Heldens Lonneke, Ayoubi Torik A, Hofker Marten H, Wouters Bradly G, Vlietinck Robert, Sinsheimer Janet S, Taskinen Marja-Riitta, Kuusisto Johanna, Laakso Markku, de Bruin Tjerk W A, Pajukanta Päivi, Glembotski Christopher C
Abstract excerpt
OBJECTIVE: Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes. We used a 2-stage design to investigate whether ATF6 polymorphisms are associated with lipids in subjects at increased risk for cardiovascular disease (CVD). METHODS AND RESULTS: In stage 1, 13 tag-SNPs were tested for association in Dutch samples...
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