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The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight.

International journal of obesity (2005) - 1 Nov 2024

Klyosova Elena, Azarova Iuliia, Petrukhina Irina, Khabibulin Ramis, Polonikov Alexey

Abstract excerpt

BACKGROUND: Numerous studies have demonstrated that the onset of type 2 diabetes (T2D) is linked to the reduction in ß-cell mass caused by apoptosis, a process initiated by endoplasmic reticulum (ER) stress. The aim of this study was to investigate the associations between single nucleotide polymorphisms (SNPs) in the ATF6 gene (activating transcription factor 6), a key sensor of ER stress, and T2D...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39134692
DOI: 10.1038/s41366-024-01604-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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