Article
Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians.
The Journal of clinical endocrinology and metabolism - 1 Jul 2007
Meex Steven J R, van Greevenbroek Marleen M J, Ayoubi Torik A, Vlietinck Robert, van Vliet-Ostaptchouk Jana V, Hofker Martin H, Vermeulen Vicky M M-J, Schalkwijk Casper G, Feskens Edith J M, Boer Jolanda M A, Stehouwer Coen D A, van der Kallen Carla J H, de Bruin Tjerk W A
Abstract excerpt
CONTEXT: Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians. OBJECTIVES: To investigate the broader significance of this association for DM2, replication studies in distinct ethic populations are required. We investigated ATF6 for...
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