Article
Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers.
Transplantation proceedings - 1 Nov 2011
Fougeray S, Loriot M-A, Nicaud V, Legendre C, Thervet E, Pallet N
Abstract excerpt
OBJECTIVES: Endoplasmic reticulum stress has been implicated in the pathogenesis of new-onset diabetes after transplantation (NODAT) and of metabolic disorders. Activated Transcription Factor 6 (ATF6), which is activated during endoplasmic reticulum stress, is involved in lipogenesis and gluconeogenesis. Tacrolimus may induce endoplasmic reticulum stress in pancreatic beta cells. Since studies have demonstrated...
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