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Article

Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians.

Diabetes - 1 Mar 2006

Thameem Farook, Farook Vidya S, Bogardus Clifton, Prochazka Michal

Abstract excerpt

Activating transcription factor 6 (ATF6) is important for protective cell response to accumulation of unfolded and misfolded proteins in endoplasmic reticulum, and disturbances of this process can contribute to beta-cell apoptosis. We analyzed the structural gene located within a region on 1q21-q...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16505252
DOI: 10.2337/diabetes.55.03.06.db05-1002

Genes

ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16505252-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians.PMID 16505252Read ↗

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.Semantic proximity Read ↗

Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians.Semantic proximity Read ↗

The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight.Semantic proximity Read ↗

Obesity has an interactive effect with genetic variation in the activating transcription factor 6 gene on the risk of pre-diabetes in individuals of Chinese Han descent.Semantic proximity Read ↗

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.Semantic proximity Read ↗

Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population.Semantic proximity Read ↗

Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers.Semantic proximity Read ↗

Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population.Semantic proximity Read ↗

A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q.Semantic proximity Read ↗

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.Semantic proximity Read ↗

A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level.Semantic proximity Read ↗

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.Semantic proximity Read ↗

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