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Article

Whole-exome sequencing identifies a novel INS mutation causative of maturity-onset diabetes of the young 10.

Journal of molecular cell biology - 1 Oct 2017

Yan Jing, Jiang Feng, Zhang Rong, Xu Tongfu, Zhou Zhou, Ren Wei, Peng Danfeng, Liu Yong, Hu Cheng, Jia Weiping

Abstract excerpt

Monogenic diabetes is often misdiagnosed with type 2 diabetes due to overlapping characteristics. This study aimed to discover novel causative mutations of monogenic diabetes in patients with clinically diagnosed type 2 diabetes and to explore potential molecular mechanisms. Whole-exome sequencing was performed on 31 individuals clinically diagnosed with type 2 diabetes. One novel heterozygous mutation...

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Topics

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Share to Age of Onset
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

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Share to Genetic Association Studies

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Source

Identifiers

PMID: 28992123
DOI: 10.1093/jmcb/mjx039

Genes

INS
ATF4
ATF6
XBP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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