Article
Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2018
Lee Won-Chul, Diao Lixia, Wang Jing, Zhang Jianhua, Roarty Emily B, Varghese Susan, Chow Chi-Wan, Fujimoto Junya, Behrens Carmen, Cascone Tina, Peng Weiyi, Kalhor Neda, Moran Cesar A, Weissferdt Annikka, Johnson Faye M, William William N, Swisher Stephen G, Lee J Jack, Hong Waun Ki, Heymach John V, Wistuba Ignacio I, Futreal P Andrew, Zhang Jianjun
Abstract excerpt
Intra-tumor heterogeneity may be present at all molecular levels. Genomic intra-tumor heterogeneity at the exome level has been reported in many cancer types, but comprehensive gene expression intra-tumor heterogeneity has not been well studied. Here, we delineated the gene expression intra-tumor heterogeneity by exploring gene expression profiles of 35 tumor regions from 10 non-small cell lung cancer tumors...
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