Article
Multiregional sequence revealed SMARCA4 R1192C mutant clones acquired EGFR C797S mutation in the metastatic site of an EGFR-mutated NSCLC patient.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2020
Kunimasa Kei, Hirotsu Yosuke, Miyashita Yoshihiro, Goto Taichiro, Amemiya Kenji, Mochizuki Hitoshi, Samamoto Ikuko, Ohki Takamasa, Oyama Toshio, Honma Keiichiro, Imamura Fumio, Nishino Kazumi, Kumagai Toru, Omata Masao
Abstract excerpt
OBJECTIVES: Intratumor heterogeneity (ITH) is reportedly involved in the clinical course and in the response to treatment, although the detailed mechanism underlying this effect remains unclear. In this study, we investigated the effect of epithelial growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment on ITH with an EGFR-mutated lung cancer patient using the multiregional sequence (MRS) analysis...
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