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Recent advances and current issues in single-cell sequencing of tumors.

Cancer letters - 28 Aug 2015

Sun Hai-Jian, Chen Jian, Ni Bing, Yang Xia, Wu Yu-Zhang

Abstract excerpt

Intratumoral heterogeneity is a recently recognized but important feature of cancer that underlies the various biocharacteristics of cancer tissues. The advent of next-generation sequencing technologies has facilitated large scale capture of genomic data, while the recent development of single-cell sequencing has allowed for more in-depth studies into the complex molecular mechanisms of intratumoral...

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PMID: 26003306
DOI: 10.1016/j.canlet.2015.04.022

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