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Article

Multiregion sequencing reveals the intratumor heterogeneity of driver mutations in TP53-driven non-small cell lung cancer.

International journal of cancer - 1 Jan 2017

Zhang Le-Le, Kan Mengyuan, Zhang Man-Man, Yu Sha-Sha, Xie Hui-Jun, Gu Zhao-Hui, Wang Hai-Ning, Zhao Shuang-Xia, Zhou Guang-Biao, Song Huai-Dong, Zheng Cui-Xia

Abstract excerpt

Intratumor heterogeneity (ITH) in non-small cell lung cancer (NSCLC) may account for resistance after a period of targeted therapies because drugs destroy only a portion of tumor cells. The recognition of ITH helps identify high-risk patients to make effective treatment decisions. However, ITH studies are confounded by interpatient heterogeneity in NSCLC and a large amount of passenger mutations. To address these...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27646734
DOI: 10.1002/ijc.30437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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