Article
IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity.
Scientific reports - 16 Feb 2016
Avnir Yuval, Watson Corey T, Glanville Jacob, Peterson Eric C, Tallarico Aimee S, Bennett Andrew S, Qin Kun, Fu Ying, Huang Chiung-Yu, Beigel John H, Breden Felix, Zhu Quan, Marasco Wayne A
Abstract excerpt
IGHV polymorphism provides a rich source of humoral immune system diversity. One important example is the IGHV1-69 germline gene where the biased use of alleles that encode the critical CDR-H2 Phe54 (F-alleles) to make broadly neutralizing antibodies (HV1-69-sBnAb) to the influenza A hemagglutinin stem domain has been clearly established. However, whether IGHV1-69 polymorphism can also modulate B cell function...
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