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Article

Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus.

Immunity - 13 Sept 2022

Sangesland Maya, Torrents de la Peña Alba, Boyoglu-Barnum Seyhan, Ronsard Larance, Mohamed Faez Amokrane Nait, Moreno Thalia Bracamonte, Barnes Ralston M, Rohrer Daniel, Lonberg Nils, Ghebremichael Musie, Kanekiyo Masaru, Ward Andrew, Lingwood Daniel

Abstract excerpt

Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1 influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but not leucine (L54) within their CDRH2 loops. Despite this, we demonstrated that both alleles encode for human IAV bnAbs that employ structurally convergent modes of contact to the same epitope. To resolve differences in lineage...

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Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Source

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Identifiers

PMID: 35952670
DOI: 10.1016/j.immuni.2022.07.006
PMCID: PMC9474600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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