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Article

Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.

American journal of respiratory cell and molecular biology - 1 May 2015

Singer Benjamin D, Mock Jason R, Aggarwal Neil R, Garibaldi Brian T, Sidhaye Venkataramana K, Florez Marcus A, Chau Eric, Gibbs Kevin W, Mandke Pooja, Tripathi Ashutosh, Yegnasubramanian Srinivasan, King Landon S, D'Alessio Franco R

Abstract excerpt

Acute respiratory distress syndrome (ARDS) is a common and often fatal inflammatory lung condition without effective targeted therapies. Regulatory T cells (Tregs) resolve lung inflammation, but mechanisms that enhance Tregs to promote resolution of established damage remain unknown. DNA demethylation at the forkhead box protein 3 (Foxp3) locus and other key Treg loci typify the Treg lineage. To test how dynamic...

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Identifiers

PMID: 25295995
DOI: 10.1165/rcmb.2014-0327OC
PMCID: PMC4491142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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