Article

Microbiota-derived inosine programs protective CD8 <sup>+</sup> T cell responses against influenza in newborns

2024-04-13

Abstract excerpt

The immunological defects causing susceptibility to severe viral respiratory infections due to early-life dysbiosis remain ill-defined. Here, we show that influenza virus susceptibility in dysbiotic infant mice is caused by CD8 + T cell hyporesponsiveness and diminished persistence as tissue-resident memory cells. We describe a previously unknown role for nuclear factor interleukin 3 (NFIL3) in repression of memo...

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Identifiers and source

Literature Corpus work: 92313983-bdfc-57f8-a74a-31586ac455a1
DOI: 10.1101/2024.04.09.588427

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