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Restoration of Foxp3+ Regulatory T Cells by HDAC-Dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology

7 Sept 2023

Abstract excerpt

Abstract Rationale Immune dysregulation is a common feature of pulmonary arterial hypertension (PAH). Histone deacetylase (HDAC)-dependent transcriptional reprogramming epigenetically modulates immune homeostasis and is a novel disease-oriented approach in modern times. Objectives To identify a novel functional link between HDAC and regulatory T cells (Tregs) in PAH, aiming to establish disease-modified...

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PMID: 37676930
DOI: 10.1164/rccm.202301-0181oc

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