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Article

IRF4-mediated Treg phenotype switching can aggravate hyperoxia-induced alveolar epithelial cell injury.

BMC pulmonary medicine - 15 Mar 2024

Langyue He, Ying Zhu, Jianfeng Jiang, Yue Zhu, Huici Yao, Hongyan Lu

Abstract excerpt

Bronchopulmonary dysplasia (BPD) is characterized by alveolar dysplasia, and evidence indicates that interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various inflammatory lung diseases. Nonetheless, the significance and mechanism of IRF4 in BPD remain unelucidated. Consequently, we established a mouse model of BPD through hyperoxia exposure, and ELISA was employed to measure...

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Identifiers

PMID: 38491484
DOI: 10.1186/s12890-024-02940-y
PMCID: PMC10941512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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