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Article

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation

1 Feb 2018

Abstract excerpt

Under physiological conditions, CD4+ regulatory T (Treg) cells expressing the transcription factor Foxp3 are generated in the thymus (tTreg) and extrathymically at peripheral sites (pTreg), and both developmental subsets play non-redundant roles in maintaining self-tolerance throughout life. Additionally, a variety of experimental in vitro and in vivo modalities can extrathymically elicit a Foxp3+ Treg cell...

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PMID: 29456534
DOI: 10.3389/fimmu.2018.00125

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