Article
Heritable change caused by transient transcription errors.
PLoS genetics - 1 Jun 2013
Gordon Alasdair J E, Satory Dominik, Halliday Jennifer A, Herman Christophe
Abstract excerpt
Transmission of cellular identity relies on the faithful transfer of information from the mother to the daughter cell. This process includes accurate replication of the DNA, but also the correct propagation of regulatory programs responsible for cellular identity. Errors in DNA replication (mutations) and protein conformation (prions) can trigger stable phenotypic changes and cause human disease, yet the ability...
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