Article
Hypermutation in bacteria and other cellular systems.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001
Bridges B A
Abstract excerpt
A temporary state of hypermutation can in principle arise through an increase in the rate of polymerase errors (which may or may not be triggered by template damage) and/or through abrogation of fidelity mechanisms such as proofreading and mismatch correction. In bacteria there are numerous examples of transient mutator states, often occurring as a consequence of stress. They may be targeted to certain regions of...
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