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Article

Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study.

PloS one - 1 Jan 2014

Lim Yen Ying, Villemagne Victor L, Laws Simon M, Ames David, Pietrzak Robert H, Ellis Kathryn A, Harrington Karra, Bourgeat Pierrick, Bush Ashley I, Martins Ralph N, Masters Colin L, Rowe Christopher C, Maruff Paul

Abstract excerpt

OBJECTIVE: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance,...

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Identifiers

PMID: 24475133
DOI: 10.1371/journal.pone.0086498
PMCID: PMC3903533

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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