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BDNF Val66Met moderates increases in CSF t-tau and p-tau181 in early sporadic Alzheimer’s disease: A prospective cohort study

2023-09-09

Abstract excerpt

<h4>Background: </h4> Allelic variation in the brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism has been shown to moderate rates of cognitive decline in preclinical sporadic Alzheimer’s disease (i.e., Aβ+ older adults), and pre-symptomatic autosomal dominant AD (ADAD). In ADAD, Met66 was also associated with greater increases in CSF levels of total-tau (t-tau) and phosphorylated tau (p-tau 181 ). T...

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Literature Corpus work
afa8177e-66d6-54b9-8ee0-ae0fb872613f
DOI
10.21203/rs.3.rs-3329091/v1
Open publication

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