Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease.

Neurobiology of aging - 1 Nov 2013

Lim Yen Ying, Villemagne Victor L, Laws Simon M, Ames David, Pietrzak Robert H, Ellis Kathryn A, Harrington Karra D, Bourgeat Pierrick, Salvado Olivier, Darby David, Snyder Peter J, Bush Ashley I, Martins Ralph N, Masters Colin L, Rowe Christopher C, Nathan Pradeep J, Maruff Paul

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment. We aimed to determine the relationship between BDNF Val66Met and beta-amyloid (Aβ) on cognitive decline, hippocampal atrophy, and Aβ accumulation over 36 months in 165 healthy adults enrolled in the Australian Imaging, Biomarkers and Lifestyle study. In healthy...

Topics

Join the communities discussing this publication.

Aniline Compounds
Brain-Derived Neurotrophic Factor
Memory, Episodic
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Positron-Emission Tomography

Psychiatric Status Rating Scales

Source

Identifiers

PMID: 23769397
DOI: 10.1016/j.neurobiolaging.2013.05.006

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease.PMID 23769397Read ↗

Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study.Semantic proximity Read ↗

BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF.Semantic proximity Read ↗

BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease.Semantic proximity Read ↗

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease.Semantic proximity Read ↗

BDNF Val66Met moderates increases in CSF t-tau and p-tau181 in early sporadic Alzheimer’s disease: A prospective cohort studySemantic proximity Read ↗

The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer’s disease: a 9-year follow-up studySemantic proximity Read ↗

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.Semantic proximity Read ↗

The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease.Semantic proximity Read ↗

Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairmentSemantic proximity Read ↗

The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease.Semantic proximity Read ↗

Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory.Semantic proximity Read ↗

Val66Met polymorphism and BDNF levels in Alzheimer's disease patients in North Indian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.